[et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” admin_label=”Hero” _builder_version=”4.19.4″ _module_preset=”default” background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/rigenerativa-header.jpg” background_position=”top_center” custom_padding=”261px||526px||false|false” custom_padding_tablet=”162px||181px||false|false” custom_padding_phone=”118px||282px||false|false” background_last_edited=”on|phone” background_image_tablet=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/rigenerativa-header-1024×683-1.jpg” background_image_phone=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/rigenerativa-mobile-683×1024-1.jpg” background_enable_image_tablet=”on” background_enable_image_phone=”on” parallax_phone=”off” background_position_tablet=”top_center” background_position_phone=”top_center” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.6″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text module_class=”ombra” _builder_version=”4.19.4″ text_font=”Raleway||||||||” text_font_size=”20px” text_line_height=”2em” header_font=”Raleway|200||on|||||” header_font_size=”53px” header_line_height=”1.4em” header_2_font=”||||||||” header_3_font=”||||||||” header_4_font=”||||||||” text_orientation=”center” background_layout=”dark” custom_margin=”||20px||false|false” custom_margin_tablet=”||15px||false|false” custom_margin_phone=”||10px||false|false” custom_margin_last_edited=”on|phone” text_font_size_tablet=”” text_font_size_phone=”16px” text_font_size_last_edited=”on|phone” header_font_size_tablet=”44px” header_font_size_phone=”28px” header_font_size_last_edited=”on|phone” header_line_height_tablet=”1.4em” header_line_height_phone=”1.4em” header_line_height_last_edited=”on|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ _module_preset=”default” text_font=”Raleway|300||on|||||” text_font_size=”20px” text_letter_spacing=”2px” link_text_color=”rgba(255,255,255,0.5)” text_orientation=”center” background_layout=”dark” disabled=”on” global_colors_info=”{}” link_text_color__hover_enabled=”on|desktop” link_text_color__hover=”#FFFFFF”]<\/p>\n
ORECCHIE A SVENTOLA<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” module_class=”mobile-reverse” _builder_version=”4.19.4″ background_color=”#222222″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/cellule-staminali.jpg” background_position=”top_center” custom_padding=”|||” custom_padding_tablet=”50%||500px||false|false” custom_padding_phone=”||350px||false|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 2!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|false|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 1!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”26px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n
Quando parliamo di uso di cellule staminali siamo spesso abituati a pensare che una cellula staminale debba spesso differenziarsi (cio\u00e8 trasformarsi un altro tipo di cellula) per rimpiazzare qualcosa che \u00e8 stato perso (per esempio in una ferita). Una logica conseguenza di questo vecchio paradigma \u00e8 quello di pensare che ci sia quasi una logica \u201cfarmacologica\u201d, ovvero tante pi\u00f9 cellule staminali andr\u00f2 a mettere in un determinato tessuto e pi\u00f9 sar\u00e0 facile cercare di riparare questo tessuto.<\/p>\n
[\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n
Quello che emerge in data odierna sono diverse \u201cdocce fredde\u201d: per prima cosa le cellule staminali adulte sono multipotenti (non si differenziano in maniera terminale, non hanno nessun fenotipo che piacerebbe ottenere in medicina rigenerativa, quindi nessun cardiomiocita efficace, nessun condrocita competente, non vasi competenti, ecc). In secondo luogo, quando si inseriscono milioni di cellule in una sede di danno, in breve tempo se ne trovano molte poche (a dir tanto il 5%, mentre il resto \u00e8 morto); la vecchia idea si basa sul fatto che in qualche modo queste cellule, inserite in un tessuto sofferente, andassero incontro a morte. Questo ha portato ulteriormente ad incrementare la ricerca scientifica per espandere queste cellule (farle moltiplicare in un ambiente ex-vivo), che di fatto diventano oggetto di quella che gli enti regolatori chiamano un prodotto di terapia medicinale avanzata.<\/p>\n
In questi anni ci siamo accorti che siamo difronte ad una realt\u00e0 molto diversa: nonostante queste condizioni cos\u00ec negative (poche cellule impiantate che sopravvivono nel tessuto sofferente e poche cellule che non si differenziano), esiste pur sempre un minimo e sottile effetto di riparazione (questo viene chiamto effetto paracrino: la cellula staminale tende a riparare il tessuto perch\u00e9 manda dei messaggi istruttivi al tessuto ricevente per cui questa in qualche modo innesta il processo di autoguarigione).<\/p>\n
[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”prima di before after” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” module_class=”mobile-reverse” _builder_version=”4.19.4″ background_color=”#000000″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/fiale-grasso.jpg” custom_padding=”|||” custom_padding_tablet=”50%||400px||false|false” custom_padding_phone=”||250px||false|false” custom_padding_last_edited=”on|tablet” background_last_edited=”off|desktop” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|true|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|phone” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text ul_item_indent=”19px” module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_font=”|300|||||||” header_3_text_color=”#ffffff” header_3_font_size=”21px” header_3_line_height=”1.3em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n
Quindi se noi vogliamo potenziare il processo di guarigione da parte della tipologia di cellule che vogliamo trapiantare, qual \u00e8 il problema? Fino ad oggi tutte le tecniche che possediamo per recuperare le cellule da un tessuto sono tecniche di manipolazione in quanto utilizzano gli enzimi per dissociare le cellule da qualunque tessuto, che sia tessuto adiposo, midollo osseo o qualunque altra fonte, utilizzano centrifugazioni multiple e ripetute e usano la cottura in vitro; tuto questo distrugge quello che \u00e8 il micro-ambiente in cui le cellule staminali vivono. Le cellule staminali infatti non \u201cnuotano\u201d nei tessuti, ma si trovano in strutture ben precise, un micro-ambiente chiamato nicchia-vasculo stromale, che \u00e8 una nanotopografia particolare. Solo in quell\u2019ambiente le cellule riescono a capire il problema di un tessuto e a mandare messaggi opportuni per riparare il tessuto.<\/p>\n
[\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n
Con un device che sfrutta forze meccanice lievi si pu\u00f2 processare il lipoaspirato iniziale in cluster pi\u00f9 piccoli attraverso dei filtri. L\u2019importante in una processazione di tessuto \u00e8 salvare la nicchia vascolo-stromale (SVF), che \u00e8 la stessa in tutti i tessuti: il fatto di parlare di tessuto adiposo \u00e8 solo una questione di facilit\u00e0 di prelievo. La nicchia da tessuto adiposo \u00e8 costituito da un cono centrale di adipociti e pre-adipociti circondata da capillari con parete molto spessa: le cellule staminali vivono proprio l\u00e0 dentro, non nuotano nei tessuti e sono essenzialmente periciti e cellule mesenchimali. Ad oggi, alcuni studiosi non li considerano cellule staminali mentre altri le ritengono anche precursori fenotipici delle stesse cellule staminali, ma in realt\u00e0 si scambiano continuamente queste caratteristiche, questi due tipi di cellule.<\/p>\n
La cosa interessante \u00e8 che questa struttura tessutale particolare mantiene la crioconservazione, cio\u00e8 non perde lo status di tessuto. Infatti dopo congelamento in azoto liquido e scongelamento, la nicchia rimane mutata e contiene al suo interno sempre periciti e cellule mesenchimali.<\/p>\n
Il tessuto adiposo microfratturato con preservazione della nicchia vasculo-stromale \u00e8:<\/p>\n
[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.19.4″ background_color=”#C49A3D” global_module=”29529″ locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.19.4″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_toggle title=”CONTATTACI” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C49A3D” closed_toggle_background_color=”#C49A3D” icon_color=”#FFFFFF” toggle_icon=”L||divi||400″ use_icon_font_size=”on” icon_font_size=”32px” open_icon_color=”#FFFFFF” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#FFFFFF” title_level=”h3″ title_font=”|300||on|||||” title_text_align=”center” title_font_size=”24px” title_letter_spacing=”2px” title_line_height=”1.2em” body_font=”|300|||||||” body_text_color=”#FFFFFF” body_font_size=”21px” body_line_height=”1.8em” background_color=”#C49A3D” width=”60%” width_tablet=”100%” width_phone=”100%” width_last_edited=”on|desktop” module_alignment=”center” custom_padding=”|||33px|false|false” border_color_all=”#FFFFFF” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n
COMPILA IL SEGUENTE MOUDLO PER RICHIEDERE UNA VISITA MEDICA CON IL DOTTORE.<\/p>\n
COSTO DELLA VISITA [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”ok” _builder_version=”4.19.4″ _module_preset=”default” background_color=”#000000″ global_colors_info=”{}”][et_pb_row _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n In tutti i casi ambulatoriali e non effettuati con l\u2019innesto di hADSCs e di tessuto adiposo micronizzato non si \u00e8 mai registrato un caso d\u2019infezione. Attualmente i ricercatori stanno indangando su un possibile effetto antibioticio rilasciato dalle hADSCs: sembrerebbe che le cellule staminali da tessuto adiposo secernono un peptide antimicrobico denominato HCAP-18\/LL37. L\u2019idea pi\u00f9 prossima \u00e8 quella di dimostrare che la processazione del grasso senza la centrifugazione ma con dispositivi biomedicali di ultima generazione possa in qualche modo attivare meccanicamente queste cellule, cio\u00e8 lo stimolo fisico che subiscono durante il lavaggio e la riduzione di volume porta a meccanismi intracellulari di attivazione genica e conseguente rilascio di alcune molecole, tra cui il peptide HCAP-18\/LL37.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”prima di before after” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” _builder_version=”4.19.4″ background_color=”#000000″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/grasso_adiposo.jpg” custom_padding=”|||” custom_padding_tablet=”50%||400px||false|false” custom_padding_phone=”||250px||false|false” custom_padding_last_edited=”on|tablet” background_last_edited=”off|desktop” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|true|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|phone” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text ul_item_indent=”19px” module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_font=”|300|||||||” header_3_text_color=”#ffffff” header_3_font_size=”21px” header_3_line_height=”1.3em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n Sull\u2019aspetto normativo dell\u2019utilizzo delle cellule staminali si assiste a questi due fenomeni: EMA (European Medicines Agency) ed FDA (Food and Drug Administration) che avevano notevole differenza sulla concezione nella cellula staminale e sulle modalit\u00e0 di conservazione delle stesse, oggi presentano pi\u00f9 o meno le stesse norme, norme che per\u00f2 sono in continua evoluzione, tant\u2019\u00e8 che non si parla pi\u00f9 di GMP ma di cGMP, per dire che \u00e8 una normativa in continua evoluzione e che rende sostanzialmente difficilissimo poter affermare oggi qualcosa ed avere la garanzia che il mese dopo sia ancora cos\u00ec.<\/p>\n<\/div>\n [\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n In questo nuovo ed innovativo dispositivo di riduzione del tessuto adiposo siamo difronte non tanto a cellule staminali ma ad un tessuto tridimensionale che le contiene; ci\u00f2 esula dalle normative, cio\u00e8 non \u00e8 un ATMP (Advanced Therapy Medicinal Products), cio\u00e8 un prodotto medicinale di terapia avanzata, non richiede il GMP. Ci\u00f2 non accade per una cellula staminale espansa, cio\u00e8 coltivata in vitro: infatti viene considerata sottoposta a manipolazione maggiore e la cell-factory (banca dei tessuti) deve provvedere ad espandere le cellule, a congelarle e a fornirle in ultimo step al chirurgo. La riduzione dei cluster adipocitari, mantenendo la struttura tridimensionale, \u00e8 tecnicamente un trapianto di tessuto adiposo e non di cellule staminali adulte, il che pu\u00f2 benissimo essere effettuato sottoforma di lipofilling, attuato sin dal 1985 ad oggi.<\/p>\n [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” _builder_version=”4.19.4″ background_color=”#222222″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/cellule_grasso.jpg” background_position=”top_center” custom_padding=”|||” custom_padding_tablet=”50%||500px||false|false” custom_padding_phone=”||350px||false|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 2!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|false|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 1!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”28px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n L\u2019altra differenza sostanziale dal punto di vista normativo \u00e8 che dall\u2019anno scorso (anno 2013) le cellule staminali non sono prodotti di terapia consolidabile: vuol dire che \u00e8 vietato l\u2019uso compassionevole, non possono essere utilizzate. L\u2019uso compassionevole riguarda solo per un farmaco gi\u00e0 applicato per un determinato uso che viene utilizzato per altri usi.<\/p>\n Ma quello che voglio sottolineare \u00e8 che non sono farmaci! Un conto \u00e8 una terapia biologica, un conto \u00e8 una terapia farmacologica. Il fatto stesso che mettano nei criteri di validazione di un prodotto di una cellula il numero di cellule e la dose minima efficace \u00e8 pura follia, queste sono persone che hanno studiato poco e che avrebbero tornare sui libri di biologia e vedere questa doccia fredda di cui vi parlavo: cio\u00e8 di tante cellule messe non ne rimane quasi nessuna, quindi non \u00e8 un problema di dose-tempo, non \u00e8 un problema di quante cellule inserisco!<\/p>\n [\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n Con questo tipo di strategia tessutale con cluster adiposi micro-fratturati e preservazione della nicchia vasculo-stromale la cell-factory siamo noi, le cellule si espandono all\u2019interno del nostro organismo e quindi \u00e8 completamente diverso proprio perch\u00e9 vivono in un tessuto che viene trapiantato, quindi vi \u00e8 consentito l\u2019uso compassionevole, pu\u00f2 andare nelle banche che non hanno necessit\u00f2 del cGMP ed \u00e8 consentito il bancaggio autologo per legge.<\/p>\n La tecnica tradizionale utilizzata fino ad oggi, per quanto riguarda la processazione di tessuto adiposo, prevede la centrifugazione: ci\u00f2 ha due aspetti fortemente limitativi; in primo luogo, la forza meccanica della centrifugazione uccide una buona percentuale di cellule staminali contenute all\u2019interno delle siringhe; in secondo luogo la separazione e lo scarto dei materiali pro-infiammatori (olio) viene fortemente limitata, sia perch\u00e9 la forze meccanica riesce solo in parte a separare il liquido, sia perch\u00e9 la sua successiva eliminazione \u00e8 operatore-manuale, quindi non standardizzabile.<\/p>\n La cellula staminale stessa non ripara direttamente il tessuto, ma sono i fattori trofici secreti da queste cellule che tendono ad agire sul tessuto ricevente. Allora la domanda classica \u00e8: una volta identificati questi fattori non \u00e8 possibile iniettare solo queste citochine per poi riparare il tessuto anche in assenza del trapianto delle cellule staminali? La risposta \u00e8 no! Perch\u00e9 sicuramente la nicchia \u00e8 una sorta di \u201claboratorio di biologia molecolare\u201d che viene messo in piazza stabile in un tessuto sofferente.<\/p>\n [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”ok” _builder_version=”4.19.4″ _module_preset=”default” background_color=”#000000″ global_colors_info=”{}”][et_pb_row _builder_version=”4.19.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n Fino a poco tempo fa il tessuto adiporo prelevato dal paziente (lipoaspirato) veniva centrifugato e re-introdotto all\u2019interno dello stesso paziente ma in un sito tissutale ricevente diverso oppure veniva inviato a una banca tessutale, dove veniva digerito con enzimi e collagenasi per estrarre dalla nicchia vascolo-stromale (SVF) la singola cellula staminale derivata da tessuto adiposo. Questa procedura, oltre a distruggere l\u2019ambiente fondamentale per la sopravvivenza di queste cellule in vivo, danneggia gravemente il \u201cglicocalice\u201d della cellula, ovvero un\u2019insieme di antenne che consentono alla staminali di captare il tipo di tessuto in cui vengono trapiantate e quale tipo d\u2019infiammazione andare a spegnere. Una volta isolata la singola staminale, veniva fatta moltiplicare con stimoli e terreni di coltura particolari in modo da ottenere anche diversi tipi di tessuto mesenchimale da re-introdurre nel paziente in un secondo tempo chirurgico.<\/p>\n Tutto questo oggi va a perdere il proprio razionale, soprattutto perch\u00e9 il mantenimento della SVF \u00e8 essenziuale per una risposta riparativa concreta, e dal punto di vista dell\u2019ingegneria tissutale le cellule staminali con SVF, introdotte in un semplice terreno di coltura, provvedono da sole alla propria replicazione.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”prima di before after” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” _builder_version=”4.19.4″ background_color=”#000000″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/grasso_in_eccesso.jpg” custom_padding=”|||” custom_padding_tablet=”50%||400px||false|false” custom_padding_phone=”||250px||false|false” custom_padding_last_edited=”on|tablet” background_last_edited=”off|desktop” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|true|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|phone” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text ul_item_indent=”19px” module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_font=”|300|||||||” header_3_text_color=”#ffffff” header_3_font_size=”21px” header_3_line_height=”1.3em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n L\u2019utilizzo delle cellule staminali embrionali ha creato accesi di battiti a livello bioetico, perch\u00e9 \u00e8 chiaro che qualsiasi sperimentazione su tali cellule riguarda da vicino l\u2019origine della vita: infatti molto spesso l\u2019estrazione di cellule staminali dall\u2019embrione provoca la distruzione e la morte dell\u2019embrione stesso; dall\u2019altro lato invece troviamo la clonazione riproduttiva, con tutte le sue riserve di sicurezza che hanno limitato l\u2019applicazione della clonazione terapeutica in attesa di una maggiore chiarezza di informazione e di dati scientifici totalmente tranquillizzanti. Non si dimentichi inoltre che le cellule staminali embrionali vengono utilizzate per la realizzazione di organismi geneticamente modificati, che possono far comprendere tuttavia alcune patologie su base genetica.<\/p>\n [\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n La medicina rigenerativa si base invece sull\u2019utilizzo di cellule staminali adulte, quindi \u00e8 una medicina sicura, \u00e8 una medicina che riapre le speranze di cura per quelle numerose patologie ad oggi destinate a lunghi trattamenti farmacologici con limitata efficacia e numerosi effetti collaterali, \u00e8 una medicina che in un futuro non cos\u00ec lontano potr\u00e0 sostituire il trapianto d\u2019organo, \u00e8 una medicina che rispetta i principi bioetici, non provoca la morte di nessun embrione, non favorisce la clonazione.<\/p>\n Tra le cellule staminali di tipo adulto, quelle che pi\u00f9 vengono pi\u00f9, conosciute sono quelle presenti nel midollo osseo, infatti abbiamo quella della linea ematopoietica, di cui \u00e8 anni che si sfruttano le loro potenzialit\u00e0, per esempio nel trapianto del midollo osseo nelle leucemie, nei linfomi.<\/p>\n La scoperta strepitosa degli ultimi anni \u00e8 che queste cellule sono presenti anche nel tessuto adiposo, e sono presenti in gran numero, ce ne sono addirittura di pi\u00f9 che nel midollo osseo percentualmente. La difficolt\u00e0\u00a0 \u00e8 estrarle, cio\u00e8 tirarle fuori.<\/p>\n [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About” _builder_version=”4.19.4″ background_color=”#ffffff” custom_padding=”0px||0px||true” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” padding_top_bottom_link_1=”true” padding_top_bottom_link_2=”true” padding_left_right_link_1=”true” padding_left_right_link_2=”true” _builder_version=”4.19.4″ background_color=”#222222″ width=”100%” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”0px||0px|” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.19.4″ background_color=”#000000″ background_image=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2023\/01\/lipo_bianco-01.png” background_position=”top_center” custom_padding=”|||” custom_padding_tablet=”50%||500px||false|false” custom_padding_phone=”||350px||false|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 2!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”display: none!important;” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.19.0″ background_color=”#000000″ custom_padding=”7%|7%|7%|7%” custom_padding_tablet=”|10%||10%|false|true” custom_padding_phone=”60px||60px||true|false” custom_padding_last_edited=”on|tablet” custom_css_main_element=”order: 1!important;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=” ” custom_css_main_element_phone=” “][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”26px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n La cosa straordinaria \u00e8 che queste cellule, estratte e preservate con un device particolare, hanno un enormi vantaggi: uno, \u00e8 che queste cellule sono quasi ubiquitarie, cio\u00e8 chiunque di noi ha una quantit\u00e0 minima di tessuto adiposo; due, \u00e8 abbastanza semplice prelevarle, basta una mini-liposuzione localizzata e quindi totalmente mini-invasiva per prelevare una quantit\u00e0 sicuramente sufficiente a fare una coltivazione di queste cellule, ma anche per averne un numero sufficiente per un uso immediato.<\/p>\n Hanno ottime caratteristiche biologiche, cio\u00e8 sono cellule che possono ancora differenziarsi in tutti i tessuti, possono essere bancate per usi futuri, quindi uno le preleva a 30 anni e guarisce come guarirebbe a 30 anni e non come guarirebbe a 70 anni quando magari gli si presenta un problema.<\/p>\n [\/et_pb_text][et_pb_toggle title=”Scopri di pi\u00f9” open_toggle_text_color=”#C49A3D” open_toggle_background_color=”#000000″ closed_toggle_background_color=”#000000″ icon_color=”#C49A3D” toggle_icon=”||fa||400″ use_icon_font_size=”on” icon_font_size=”17px” open_icon_color=”#C49A3D” open_toggle_icon=”)||divi||400″ open_use_icon_font_size=”on” open_icon_font_size=”27px” _builder_version=”4.19.4″ _module_preset=”default” title_text_color=”#b7b7b7″ title_level=”h3″ title_font=”|||on|||||” title_font_size=”17px” title_line_height=”1.2em” body_text_color=”#b7b7b7″ body_line_height=”1.8em” background_color=”#000000″ width=”100%” custom_padding=”|||0px|false|false” border_width_all=”0px” border_color_all=”#C49A3D” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n Queste cellule costituiscono un prodotto tessutale autologo, ovvero \u00e8 materiale prelevato e re-iniettato nello stesso paziente, quindi \u00e8 privo di effetti collaterali, non provoca reazioni allergiche, non \u00e8 una tecnica dolorosa poich\u00e9 viene somministrato attraverso micro-punture con un ago-cannula molto sottile.<\/p>\n Sono cellule che sono molto stabili geneticamente, recenti congressi come quello del Dicembre 2012 a Roma e il secondo congresso della Societ\u00e0 Internazionale di Chirurgia Plastica Rigenerativa (ISPRES) del Giugno 2013 a Berlino, hanno dimostrato che sono stabili geneticamente anche dopo diverse differenziazioni e questo \u00e8 importante per la sicurezza che deve essere sempre la prima preoccupazione di chiunque si occupi di questo campo.<\/p>\n [\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”ok” _builder_version=”4.19.4″ _module_preset=”default” background_color=”#000000″ global_colors_info=”{}”][et_pb_row _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text module_class=”free-section-header free-db-dark” _builder_version=”4.19.4″ text_font=”||||||||” text_text_color=”#999999″ text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_text_color=”#C49A3D” header_2_font_size=”35px” header_2_line_height=”1.2em” header_3_text_color=”#b7b7b7″ header_3_line_height=”1.2em” header_4_font=”|||on|||||” header_4_text_color=”rgba(255,255,255,0.4)” header_4_font_size=”15px” header_4_letter_spacing=”2px” header_4_line_height=”1.6em” background_layout=”dark” module_alignment=”left” header_2_font_size_tablet=”42px” header_2_font_size_phone=”27px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n Lo scopo della Medicina e Chirurgia Rigenerativa non \u00e8 quello di rimpiazzare ci\u00f2 che nel corpo umano non \u00e8 pi\u00f9 in grado di funzionare, ma quello di\u00a0fornire gli elementi necessari per una sua riparazione in vivo<\/em>, di inventare sostituti e presidi in grado di fondersi con il corpo umano e di stimolare e sostenere le capacit\u00e0 intrinseche del nostro corpo a rigenerarsi e a guarire da solo.<\/p>\n La Medicina Rigenerativa \u00e8 un settore interdisciplinare che ha la prospettiva di\u00a0riparare, sostituire e rigenerare<\/em>\u00a0cellule, tessuti e organi al fine di ripristinare alcune funzioni anatomiche, fisiologiche e biochimiche deteriorate per cause differenti (difetti congeniti, malattie, traumi ed invecchiamento).<\/p>\n E\u2019 stato stimato dal Fondo Monetario Internazionale che l\u2019aumento di soli 3 anni della vita media della popolazione mondiale fara\u0300 lievitare del 50% i costi dei servizi sanitari.<\/p>\n La fonte ideale di cellule staminali per applicazioni cliniche deve idealmente soddisfare i seguenti criteri:<\/p>\n il tessuto adiposo \u00e8 considerato pertanto la fonte ideale che soddisfa tali criteri.<\/p>\n Il tessuto adiposo \u00e8 una delle primarie fonti di cellule staminali mesenchimali (hMSC). Indipendentemente dal tessuto di provenienza, esse hanno dimostrato un\u00a0destino vasculogenico<\/u>\u00a0(riparazione vascolare) in vitro e in vivo. Hanno la caratteristica di poter esprimere un insieme di\u00a0fattori trofici<\/u>\u00a0(che concorrono a nutrire la cellula. Senza di essi la cellula muore) secernibili in diverse condizioni ambientali. Tali fattori individuano una\u00a0peculiarit\u00e0 di tipo paracrino<\/u>\u00a0(inviano messaggi da una cellula all\u2019altra al fine di modificare la fisiologia delle cellule circostanti), inducendo risposte\u00a0angiogenetiche, antiapoptotiche e antifibrotiche.<\/u><\/p>\n Le ADSC possono essere indirizzate verso un destino endoteliale, muscolare liscio, condrocitario, ematopoietico, epatocitario, simil-neuronale, osteoblastico, pancreatico, muscolo-scheletrico, miocardico e vascolare.<\/p>\n 1 g di tessuto adiposo contiene approssimativamente 5\u00d7103<\/sup>\u00a0MSCs, circa 500 volte maggiore rispetto ad 1 g di bone marrow (midollo osseo)<\/p>\n Esistono numerosi esempi in letteratura che dimostrano la multipotenza\u00a0in vitro\u00a0<\/strong>delle cellule staminali estratte dal tessuto adiposo.\u2028Infatti, le ADSCs sono di origine mesodermica la cui potenziale differenziazione include cellule adipose, osteogeniche, condrogeniche, miogeniche oltre a fibroblasti, tenociti e cardiomiociti.<\/p>\n Altri studi hanno dimostrato anche il potenziale di differenziazione in linee non- mesodermiche, inclusi simil-neuroni, cellule endoteliali, epiteliali, epatociti, cellule pancreatiche ed ematopoietiche.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”#C49A3D” global_module=”29524″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/plasticsurgerymc.com\/wp-content\/uploads\/2022\/11\/Mattia-Colli-Logo-color.png” alt=”Mattia Colli medico chirurgo logo” title_text=”Mattia-Colli-Logo-color” align=”center” _builder_version=”4.19.0″ _module_preset=”default” filter_brightness=”200%” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” text_font=”|300||on|||||” text_text_color=”#FFFFFF” text_font_size=”21px” text_letter_spacing=”2px” locked=”off” global_colors_info=”{}”]<\/p>\n DR. MATTIA COLLI<\/p>\n [\/et_pb_text][et_pb_contact_form title=”CONTATTACI” submit_button_text=”Invia” _builder_version=”4.19.4″ _module_preset=”default” _unique_id=”f8ba6b6d-5ced-4f57-8149-87acf2c6b63c” form_field_background_color=”#FFFFFF” form_field_text_color=”#000000″ title_font=”|300|||||||” title_text_align=”center” title_letter_spacing=”3px” title_line_height=”2.4em” captcha_text_color=”#000000″ form_field_font=”|||on|||||” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#000000″ button_border_width=”0px” button_border_radius=”0px” button_font=”|||on|||||” locked=”off” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nome” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” 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button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Messaggio” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” 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global_colors_info=”{}”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Code For Before After Slider” module_class=”free-code-explainer-wrapper” _builder_version=”4.16″ _module_preset=”default” background_color=”#f7f7f7″ locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_code admin_label=”Code For Before After Slider” module_class=”free-before-after-slider-code-explainer” _builder_version=”4.16″ saved_tabs=”all” global_colors_info=”{}”]\tjQuery(function($){ $(“.free-293-dark”).twentytwenty({ before_label: ‘Before’, \/\/ Set a custom before label after_label: ‘After’, \/\/ Set a custom after label orientation: ‘vertical’, \/\/ Orientation of the before and after images (‘horizontal’ or ‘vertical’) no_overlay: false, \/\/Do not show the overlay with before and after click_to_move: true \/\/ Allow a user to click (or tap) anywhere on the image to move the slider to that location. }); });[\/et_pb_code][et_pb_code admin_label=”CSS For Code Explainer” _builder_version=”4.16″ custom_css_main_element=”display: none!important;” saved_tabs=”all” global_colors_info=”{}”]html:not(.et-fb-root-ancestor) .free-code-explainer-wrapper, .et-fb-root-ancestor-sibling .free-code-explainer-wrapper, \t.et-fb-root-ancestor-sibling.free-code-explainer-wrapper {\tdisplay: none!important;}html.et-fb-root-ancestor .free-before-after-slider-code-explainer.et_pb_code { background: #151515!important;\toutline: 4px double rgba(255, 255, 255, 0.76); outline-offset: -18px;}html.et-fb-root-ancestor .free-before-after-slider-code-explainer.et_pb_code:before { content: ‘This is the main code for before & after slider. You may go to this code module settings & copy the code to WP Admin > Divi > Theme Options > Integration > Header Code. And lastly remove this section. The ‘before’ & ‘after’ text can be changed here as well.’; display: block; position: relative; padding: 38px; color: #fff; text-align: center; font-size: 18px; font-weight: 800; text-transform: uppercase; line-height: 1.7em;}[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" MEDICINA RIGENERATIVA CON CELLULE STAMINALI DA TESSUTO ADIPOSOORECCHIE A SVENTOLA(HADSCS) \u2013 HUMAN ADIPOSE STEM CELLS WITH ADIPOSE MICROFRACTURED CLUSTERS AND PRESERVED STROMA-VASCULAR FRACTION (SVF) Quando parliamo di uso di cellule staminali siamo spesso abituati a pensare che una cellula staminale debba spesso differenziarsi (cio\u00e8 trasformarsi un altro tipo di cellula) per rimpiazzare qualcosa che \u00e8\u2026 Read More »<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-30244","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/pages\/30244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/comments?post=30244"}],"version-history":[{"count":3,"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/pages\/30244\/revisions"}],"predecessor-version":[{"id":30251,"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/pages\/30244\/revisions\/30251"}],"wp:attachment":[{"href":"https:\/\/plasticsurgerymc.com\/it\/wp-json\/wp\/v2\/media?parent=30244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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<\/strong>[divilifeshortcode id=’29534′]<\/p>\n<\/div>\n<\/div>\nANTIBIOTIC EFFECT<\/h2>\n
EMA \u2013 FDA \u2013 CURRENT LEGISLATIONS<\/h2>\n
THE NICHE THEORY FOR FAT GRAFT SURVIVAL (TISSUE ENGINEERING)<\/h2>\n
STEM CELLS<\/h2>\n
REGENERATIVE MEDICINE<\/h2>\n
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