Regenerative Medicine
Regenerative medicine refers to the surgical medical process of “regenerating” and replacing cells and tissues in one’s body to allow their restoration (sometimes even organs). This newest branch of medicine allows damaged and degenerated tissues to stimulate their own repair mechanisms in order to permanently heal damage deemed irreparable with classic drug or external machine-related treatments.
The potential to make curable pathologies and blemishes hitherto destined for long-lasting and limitedly effective mechanical and pharmacological treatments, and the future possibility of replacing organ transplantation, already make it of crucial importance.
In recent years, this area of research has become, thanks to the successes achieved pyatrin growth factors (PRP) and with the culture of different types of stem cells and with the study of proliferation, modulation and differentiation in vitro, one of the greatest hopes of medicine.
Regenerative medicine, certainly of greater understanding difficulty for the patient, presents the most innovative and potential means of using autologous biological tissue (thus from one’s own body), which does not produce side effects, allergic reactions and does not cause the danger of infection both in the plastic-aesthetic field and in the field of repair of pathological and suffering tissues.”
Platelet growth factors (PRPs) are cell (platelet) signals, so they are temporary signals. The grafting of stem cells from micronized adipose tissue is completely different because the transplantation involves the reinsertion of real cells with preserved SVF (vascular-stromal fraction); the grafted cell is very much like a “pharmaceutical company” where the production of signals is definitely superior to that of PRP, in fact, the signals emanating are constantly changing and only those necessary for the resolution of the degenerative pathology are produced.
WHAT REGENERATIVE MEDICINE AND SURGERY IS FOR
REGENERATIVE MEDICINE: TO WHOM IS IT RECOMMENDED?
PRP IS AN AUTOLOGOUS AND SAFE THERAPY
Prp is a safe and side-effect-free therapy that does not cause allergic reactions, precisely because the regenerative product is autologous material from the same person, is not a drug, and is not a painful technique because it is administered through micro-punctures with an insulin needle.
Prp is an autologous product (taken from the same person) and consists of a number of platelet growth factors, i.e., signals that reestablish orderly cellular responses where there is active inflammation (muscle tears and strains, knee and shoulder inflammation, skin burns and ulcers…) and awaken those that, for some reason, tend to shut down and block their own cellular activity (androgenetic and areata alopecia, skin aging). Thus, prp consists of a vast network of signals derived from the disruption of platelet cell membranes, so the effect and their efficacy are temporary, which is why repeated treatment is strongly indicated.
Another state-of-the-art cell therapy product are adipose tissue stem cells (hADSCs) obtained by a special method that does not involve enzymes, collagenase, or some other manipulative substance (state-of-the-art lipofilling). The adipose tissue is reduced in size, preserving not only the individual stem cells, which reside between one adipocyte and another, but also a whole series of neighboring cells, including pericytes, which are essential for proper rooting to transplantation.
The function of an adult stem cell is totally different from that of prp, precisely because the single cell is a permanent center of signal production; no longer, as in prp, are signals predefined by the rupture of platelet membranes used, but the cell itself becomes a small autonomous cell-factory and provides for the release of certain signals that the tissue needs at that particular time (skin for rejuvenation, subcutis for ulcers and scarring or postirradiation pathologies, cartilage for knee and shoulder, inflamed and painful tissues… ). So no longer merely signals that have limited if not repeated time, but their own permanent center of cytochemical signal production.
To date, therefore, we possess a state-of-the-art treatment that allows us to preserve and treat the deterioration of joint tissues, certainly due both to ‘advancing age but also from excessive joint use.